Fullmetal Alchemist
After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy taboo carries a heavy price. Ed loses his leg, and Al loses his body. Ed is able to seal Al's soul inside of a huge suit of armor, at the cost of his arm. Years later, Ed (now with two mechanical limbs) and Al (still trapped in the armor) leave their childhood home, each brother concerned with the other's happiness. Ed, who has a natural talent and skill for alchemy, becomes nationally certified and is soon known everywhere as the "Fullmetal Alchemist." Their true objective is to search for any information on the fabled Philosopher's Stone, hoping it will allow them to regain their old bodies. All of their hopes rest with this mythical stone, which may not even exist at all. However, the brothers soon learn that they are not the only ones after the powerful stone. (source: ANN)
Fullmetal Alchemist: Brotherhood
Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.(source: ANN)
